Correlation of Maternal Autoantibodies with Fetal Congenital Heart Block
نویسندگان
چکیده
منابع مشابه
Correlation of Maternal Autoantibodies with Fetal Congenital Heart Block.
BACKGROUND Autoimmune fetal congenital heart block (CHB) is the most severe manifestation of neonatal lupus, and it is seen when maternal autoimmune antibodies cross the placenta and damage the AV node of the fetus. CHB is mainly associated with maternal SLE with anti-Ro/SSA- and anti-La/SSB-positive status, and incidence of CHB increases when both the antibodies are present. This study was con...
متن کاملCongenital heart block: evidence for a pathogenic role of maternal autoantibodies
During pregnancy in autoimmune conditions, maternal autoantibodies are transported across the placenta and may affect the developing fetus. Congenital heart block (CHB) is known to associate with the presence of anti-Ro/SSA and anti-La/SSB antibodies in the mother and is characterized by a block in signal conduction at the atrioventricular (AV) node. The mortality rate of affected infants is 15...
متن کاملMaternal Anti-Ro/SSA and Anti-La/SSB Antibodies and Fetal Congenital Heart Block.
The incidence of CHB is 2 % in cases of maternal anti-Ro/ SSA antibody positivity, 3 % when both anti Ro/SSA and anti-La-SSB are positive. The risk of recurrence is 9 times higher in the subsequent pregnancies [1]. Underlying structural congenital heart disease is associated with more than half of the fetuses found to have CHB and it is then defined ‘‘isolated’’ in the absence of structural hea...
متن کاملA serologic marker for fetal risk of congenital heart block.
OBJECTIVE To analyze the humoral immune response to Ro/SSA and La/SSB antigens in detail, in order to identify markers in mothers at high risk of having children with congenital heart block (CHB). METHODS Serum samples were obtained from 9 Ro/La-positive mothers who gave birth to affected children, from their 8 newborns with CHB, and from 26 Ro/La-positive mothers whose children were healthy....
متن کاملFetal Echo Doppler for Early Detection of Congenital Heart Block
Background: Fetal echo Doppler methods, detecting prolonged atrioventricular (AV) time intervals a mechanical PR interval corresponding to the electrical PR interval in ECG, have been proposed for surveillance of pregnancies at risk of complete congenital heart block (CCHB). The aim of this thesis was; to validate these Doppler methods by comparing AV time intervals from left ventricular inflow...
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ژورنال
عنوان ژورنال: The Journal of Obstetrics and Gynecology of India
سال: 2015
ISSN: 0971-9202,0975-6434
DOI: 10.1007/s13224-015-0813-7